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 You can send SIGINT to OfflineIMAP using (~/.offlineimap/pid) to kill it. SIGUSR1 will force an immediate resync of all accounts. This will be ignored for all accounts for which a resync is already in progress.

Can someone please explain how to send a signal to a file?

In that file is stored PID (process ID) of the current running offlineimap process. You can use this number as an argument to kill command, to send signals. Like this:
kill -s SIGUSR1 `cat ~/.offlineimap/pid`
You can see more details here, Nixie 13:50, 7 February 2011 (EST)