Today I tried to install Guix and continually got name resolution errors;
Starting download of /gnu/store/63qfd5kfgw8nccnzff3r1gsmd626pcaw-tiff-4.2.0.tar.gz
In procedure getaddrinfo: Temporary failure in name resolution
failed to download "/gnu/store/63qfd5kfgw8nccnzff3r1gsmd626pcaw-tiff-4.2.0.tar.gz" from "https://download.osgeo.org/libtiff/tiff-4.2.0.tar.gz"
I resolved this through running nscd;
systemctl start nscd
It's not like I didn't have a name resolver running, since I have systemd-resolved always on. So nscd at least seems to change Guix' behaviour and might be required.